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This
blog was designed as an assignment for the
BIOL
4550 course at Memorial University of
Newfoundland
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Testosterone
is a steroid hormone, that is converted from androstenedione, by the enzyme 17-β hydroxysteroid dehydrogenase.
For this assignment, we will be looking at the mRNA sequence that encodes the gene HSD17β2. This enzyme will be compared in humans, big (cattle) and small (mouse) mammals and in the Zebra fish.
*This picture was found using the pubmed website*
Humans - Homo sapiens
>gi|306462|gb|AAA03562.1| 17 beta hydroxysteroid dehydrogenase type 2 [Homo sapiens] MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKRHFGQDKPMPRALRMPNYKKKAT
Cattle - Bos taurus
*Bos taurus is a classification that is no longer used.
It used to refer to the European Cattle, such
as the extinct Auroch.*
*this is a picture of Bos gaurus, similar to Bos taurus*
*this picture was found using Arkive*
House Mouse - Mus musculus
*this picture was found using Arkive*
>gi|123173870|ref|NP_032316.2| estradiol 17-beta-dehydrogenase 2 [Mus musculus] MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH
Zebra Fish - Danio rerio
*This picture was found using Arkive*
Translational sequence (Amino Acid sequence)
>gi|91316130|gb|ABE28409.1|
17-beta hydroxysteroid dehydrogenase 2 [Danio rerio]MYTSGIVLYVSFIRSNKRPIAFTSKWRSRGAVAVELSIERRPLVILSSLTTLYFRKIFTLAGVFSCDSGFGHELAQVLDRAGMRVFAGVLDELSPGALKLKESASVNLTVLQLDITNNTQITQTHQFIKSQTGKTGLWALVNNAGVLGYVCDGEILPMKMYKSCLDVNFLGSVMMTHTFLPLIRQSRGRVINITSMAGEVPLVGFAGYGASKAALNIYSGAIRQELSRWGVRVIIVQPGAFRTNILGSSEQWERAQEQILSGLSEEVKDSYGEEYIHSMQKRLLDMSSASSEDKGPFLQSLKHAILSSNPKHFYYPGAGAWVLSLLYRYCPTALSDKIFSGMFMSGVQPAELARAIPH
References
Freeman, Erica F., Bloom, David A., Mcguire, Edward J. (2001) A Brief History of
Testosterone. The Journal of Urology. vol 165, issue 2, pages 371- 373, issn 0022-
5347, 10.1097/00005392-200102000-00004.
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